Dynamic changes in Sox2 spatio-temporal expression direct the second cell fate decision through Fgf4/Fgfr2 signaling in preimplantation mouse embryos
Tapan Kumar Mistri, Wibowo Arindrarto, Wei Ping Ng, Choayang Wang, Leng Hiong Lim, Lili Sun, Ian Chambers, Thorsten Wohland, Paul Robson
The paper quantifies Sox2 and Oct4 synergistic binding to Sox/Oct motifs, showing Sox2 levels drive Fgf4 expression, influencing cell fate decisions in mouse embryos.
Biochemical Journal · Feb 27, 2018Peer-reviewedDevelopmental Biology