Mechano-activated chondroprogenitors (MACs) drive intrinsic cartilage repair; a process that is arrested in osteoarthritis
Linyi Zhu, Hayat Muhammad, Thomas A. Perry, Anastasia Ardasheva, Rebecca A Symons, Jessica J McClure, Karolina Kania, Susan M Clark, Fabio Colella, Lada A. Koneva, S.N. Khan, Suzanne Elizabeth Eldridge, Francesco Dell’Accio, S.C. Mastbergen, Mylène P. Jansen, , Tonia L. Vincent
The paper shows mechanical stress reprograms chondrocytes into mechano-activated chondroprogenitors (MACs) that drive cartilage repair, which is arrested in osteoarthritis.
bioRxiv · Aug 21, 2025 · PreprintCell Biology