Author

Lada A. Koneva

University of OxfordORCID 0000-0002-9529-4886Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Fiona E. WattiD· 2 shared Hayat Muhammad· 2 shared Jadwiga Miotla ZarebskaiD· 2 shared Linyi ZhuiD· 2 shared Stephen Nicholas SansomiD· 2 shared Tonia L. VincentiD· 2 shared Akira WibergiD· 1 shared Amir Hossein KayvanjooiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Fiona E. WattORCID

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Author profile →

3 papers

Recent·Most cited

Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling

Klara Piletič, Amir Hossein Kayvanjoo, Felix Clemens Richter, Mariana Borsa, Ana Victoria Lechuga‐Vieco, Oliver Popp, Sacha Grenet, Jacky K. L. Ko, Lin Luo, Kristina Zec, Maria Kyriazi, Harriet K. Haysom, Lada A. Koneva, Stephen Nicholas Sansom, Philipp Mertins, , Anna Katharina Simon

This study shows that autophagy in adipocytes limits obesity-related fibrosis by controlling purine nucleoside metabolism and macrophage polarization.

Nature Communications · Oct 17, 2025Peer-reviewedCell Biology

Mechano-activated chondroprogenitors (MACs) drive intrinsic cartilage repair; a process that is arrested in osteoarthritis

Linyi Zhu, Hayat Muhammad, Thomas A. Perry, Anastasia Ardasheva, Rebecca A Symons, Jessica J McClure, Karolina Kania, Susan M Clark, Fabio Colella, Lada A. Koneva, S.N. Khan, Suzanne Elizabeth Eldridge, Francesco Dell’Accio, S.C. Mastbergen, Mylène P. Jansen, , Tonia L. Vincent

The paper shows mechanical stress reprograms chondrocytes into mechano-activated chondroprogenitors (MACs) that drive cartilage repair, which is arrested in osteoarthritis.

bioRxiv · Aug 21, 2025 · PreprintCell Biology

Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis

Linyi Zhu, Pragash Kamalathevan, Lada A. Koneva, Jadwiga Miotla Zarebska, Anastasios Chanalaris, Heba M. Ismail, Akira Wiberg, Michael Ng, Hayat Muhammad, John Walsby-Tickle, James McCullagh, Fiona E. Watt, The Oxford Hand Surgical Team, Stephen Nicholas Sansom, Dominic Furniss, , Tonia L. Vincent

Analysis of hand OA cartilage stratified by ALDH1A2 polymorphic variants reveals a targetable, anti-inflammatory role for retinoic acid in OA.

Science Translational Medicine · Dec 21, 2022Peer-reviewedMolecular Biology