Tonia L. Vincent

The paper shows mechanical stress reprograms chondrocytes into mechano-activated chondroprogenitors (MACs) that drive cartilage repair, which is arrested in osteoarthritis.

The paper identifies CSF1 and TGFβ as key signals for synovial lining macrophage development in mice, which occurs postnatally and is monocyte-independent.

This study shows mitochondrial heteroplasmy impairs osteoclast differentiation and bone resorption by disrupting respiratory complex I and autophagy, and identifies spermidine as a potential therapeutic.

Analysis of hand OA cartilage stratified by ALDH1A2 polymorphic variants reveals a targetable, anti-inflammatory role for retinoic acid in OA.

The paper uses in vivo pulsed SILAC to measure protein incorporation in mice tissues, finding reduced turnover and molecular changes linked to aging.

This study shows that IFT88 deletion leads to reduced cartilage thickness and increased osteoarthritis in mice, with exercise partially reversing these effects.