Author

Linyi Zhu

University of OxfordORCID 0000-0001-9594-7085Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Tonia L. VincentiD· 3 shared Fiona E. WattiD· 2 shared Hayat Muhammad· 2 shared Jadwiga Miotla ZarebskaiD· 2 shared Lada A. KonevaiD· 2 shared Akira WibergiD· 1 shared Anastasia ArdashevaiD· 1 shared Anastasios ChanalarisiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

Tonia L. VincentORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 21, 2025

Mechano-activated chondroprogenitors (MACs) drive intrinsic cartilage repair; a process that is arrested in osteoarthritis

Linyi Zhu, Hayat Muhammad, Thomas A. Perry…·Tonia L. Vincent

The paper shows mechanical stress reprograms chondrocytes into mechano-activated chondroprogenitors (MACs) that drive cartilage repair, which is arrested in osteoarthritis.

1 citation

humanexperimental assay

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Molecular BiologyScience Translational MedicinePeer-reviewedDec 21, 2022

Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis

Linyi Zhu, Pragash Kamalathevan, Lada A. Koneva…·Tonia L. Vincent

Analysis of hand OA cartilage stratified by ALDH1A2 polymorphic variants reveals a targetable, anti-inflammatory role for retinoic acid in OA.

47 citationstop 2%

humanbulk RNA-seq

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Molecular BiologyArthritis & RheumatologyPeer-reviewedJun 9, 2021

The ciliary protein IFT88 controls post-natal cartilage thickness and influences development of osteoarthritis.

Clarissa R. Coveney, Linyi Zhu, Jadwiga Miotla‐Zarebska…·Angus K. T. Wann

This study shows that IFT88 deletion leads to reduced cartilage thickness and increased osteoarthritis in mice, with exercise partially reversing these effects.

39 citationstop 5%

mouseexperimental assay

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