Signatures of selection and mechanisms of insecticide resistance in Ugandan Anopheles funestus: Insights from embedding translational genomics into the LLINEUP cluster randomised trial.
Lilian Namuli-Kayondo, Sanjay Curtis Nagi, Harun Njoroge, Anastasia Hernández-Koutoucheva, Daniel P. McDermott, Samuel Gonahasa, Amy Lynd, Ambrose Oruni, Catherine Maiteki‐Sebuguzi, Jimmy Opigo, Adoke Yeka, Agaba Katureebe, Mary Kyohere, Moses Robert Kamya, Grant Dorsey, , Martin J. Donnelly
This paper uses genomic surveillance in a cluster randomized trial to detect insecticide resistance variants in Ugandan Anopheles funestus and An. gambiae s.l., showing differential population responses to pyrethroid and PBO interventions.
bioRxiv · Jun 17, 2025 · PreprintGenomics