This study uses genomic data to analyze evolutionary dynamics of Anopheles gambiae under different insecticidal tools, revealing distinct resistance mechanisms and allele frequency shifts.

Molecular Ecology · Mar 1, 2026Peer-reviewedGenomics

A novel locus associated with decreased susceptibility of Plasmodium falciparum to lumefantrine and dihydroartemisinin has emerged and spread in Uganda

Karamoko Niaré, Bersabeh Tafesse, Mayland Treat, Jacob M. Sadler, Martin Okitwi, Stephen Orena, Victor Asua, Oriana Kreutzfeld, Jenny Legac, Jacob Marglous, Samuel L. Nsobya, Adoke Yeka, Dave Richard, Michael T. Ferdig, Angana Mukherjee, , Melissa D. Conrad

bioRxiv · Jul 30, 2025 · PreprintGenomics

Signatures of selection and mechanisms of insecticide resistance in Ugandan Anopheles funestus: Insights from embedding translational genomics into the LLINEUP cluster randomised trial.

Lilian Namuli-Kayondo, Sanjay Curtis Nagi, Harun Njoroge, Anastasia Hernández-Koutoucheva, Daniel P. McDermott, Samuel Gonahasa, Amy Lynd, Ambrose Oruni, Catherine Maiteki‐Sebuguzi, Jimmy Opigo, Adoke Yeka, Agaba Katureebe, Mary Kyohere, Moses Robert Kamya, Grant Dorsey, , Martin J. Donnelly

This paper uses genomic surveillance in a cluster randomized trial to detect insecticide resistance variants in Ugandan Anopheles funestus and An. gambiae s.l., showing differential population responses to pyrethroid and PBO interventions.

bioRxiv · Jun 17, 2025 · PreprintGenomics