Hypoxic injury triggers maladaptive repair in human kidney organoids
Ana B. Nunez-Nescolarde, Yang Liao, Laura Perlaza-Jiménez, Mehran Piran, Zhengqi Cheng, Chris K. Barlow, Joel R. Steele, Deanna Deveson Lucas, Han-Chung Lee, Julie L. M. Moreau, Jinhua Li, Ralf B. Schittenhelm, Christine Anne Wells, Wei Shi, David J. Nikolic‐Paterson, Alexander N. Combes
This study uses human kidney organoids to model hypoxic injury and maladaptive repair, identifying molecular and metabolic changes associated with AKI and CKD progression.
bioRxiv · Oct 4, 2023 · PreprintSystems Biology