Holding glycolysis in check though Alox15 activity is required for macrophage M2 commitment and function in tissue repair and anti-helminth immunity.
Dovran Ovezgeldiyev, Vanessa Trefzer, Rory Doolan…·Tiffany Bouchery
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Monash UniversityORCID 0000-0002-6457-3823Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Dovran Ovezgeldiyev, Vanessa Trefzer, Rory Doolan…·Tiffany Bouchery
Emma Rybalka, Stephanie Kourakis, Bo Qi…·Cara A. Timpani
The paper identifies ADSS1 as a suppressed metabolic control node in dystrophic muscle, showing its role in purine metabolism and its impact on inflammatory and adipogenic remodelling.
Stephanie Kourakis, Cara A. Timpani, Ryan M. Bagaric…·Emma Rybalka
This study shows that moderate-term dimethyl fumarate treatment reduces dystrophic muscle pathology in a mouse model of Duchenne muscular dystrophy, with anti-inflammatory, anti-fibrotic, and anti-lipogenic effects.
Ana B. Nunez-Nescolarde, Yang Liao, Laura Perlaza-Jiménez…·Alexander N. Combes
This study uses human kidney organoids to model hypoxic injury and maladaptive repair, identifying molecular and metabolic changes associated with AKI and CKD progression.