iPSC-Derived Hepatocytes from Patients with MASLD Exhibit Early Mitochondrial Dysfunction
Dounia Le Guillou, Kevin Siao, Chris L Her, Caroline C. Duwaerts, Jacquelyn J. Maher
This study shows that iPSC-derived hepatocytes from MASLD patients show early mitochondrial dysfunction, including reduced oxygen consumption and increased ROS production, independent of PNPLA3 genotype.
bioRxiv · Aug 27, 2025 · PreprintCell Biology