Caroline C. Duwaerts

This study shows that iPSC-derived hepatocytes from MASLD patients show early mitochondrial dysfunction, including reduced oxygen consumption and increased ROS production, independent of PNPLA3 genotype.

This study shows that targeting acid ceramidase reduces fibrosis in mouse models of NASH without worsening metabolic features.

This study improves iPSC differentiation into endoderm by using doxycycline to enhance survival via AKT phosphorylation, achieving 90% endoderm formation in over 70 iPSC lines.