A novel role for the HLH protein Inhibitor of Differentiation 4 (ID4) in the DNA damage response in basal-like breast cancer.
Laura A. Baker, Christoph Krisp, Daniel Roden, Holly Holliday, Sunny Z. Wu, Simon Junankar, Aurelien A. Serandour, Hisham Mohammed, Radhika Nair, Chia-Ling Chan, Jessica Yang, Nicola Foreman, Breanna Fitzpatrick, Geetha Sankaranarayanan, Andrew M.K. Law, , Alexander Swarbrick
This study identifies ID4's role in DNA damage response in BLBC and HGSOV by showing its interaction with MDC1 and DNA repair proteins, linking it to BRCA1-mutant tumors.
bioRxiv · Mar 14, 2018 · PreprintCancer Biology