Sunny Z. Wu

The paper identifies stromal cell subsets in breast cancer that influence T-cell infiltration and patient outcomes through spatial and clinical analysis.

This study identifies fibroblast-derived TGF-β3 as a critical factor sustaining CD8+ TRM in barrier tissues and tumors, showing its role in survival and function.

This study uses single-cell RNA-sequencing and spatial transcriptomics to analyze epithelial and fibroblast states in hormone therapy-naive prostate cancer, identifying novel phenotypes and molecular perturbations.

The paper identifies Grem1-expressing fibroblastic reticular cells as a source of FLT3L that supports dendritic cell homeostasis and function in lymph nodes.

Tangram2 maps cell-to-cell communication by integrating spatial transcriptomics with single-cell RNA sequencing to identify gene expression changes driven by neighboring cell types.

This paper shows that ROCK2 inhibition reduces ECM remodelling and cell growth while impairing migration and invasion in breast cancer models.

This study identifies Dpt+ fibroblasts as essential for maintaining a Csf1-dependent macrophage niche in skin, with implications for wound healing and scleroderma.

The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.

This study identifies ID4 as a repressor of myoepithelial differentiation in mammary stem cells through its interaction with HEB, using integrated transcriptomic, proteomic, and ChIP-sequencing data.

This study identifies ID4's role in DNA damage response in BLBC and HGSOV by showing its interaction with MDC1 and DNA repair proteins, linking it to BRCA1-mutant tumors.

This study uses single-cell transcriptomics to reveal molecular subtype and functional heterogeneity in breast cancer models, identifying subpopulations with potential clinical relevance.