Christoph Krisp

The paper integrates kidney and urine proteomics with peptidomics and machine learning to identify encrypted antimicrobial peptides as functional effectors in human pyelonephritis.

This study identifies lactate as a metabolic driver of CD163+ macrophage polarization in human pyelonephritis, linking lactate metabolism to immune dysfunction.

The paper develops an ultrasensitive spatial tissue proteomics workflow capable of processing over 100 proteomes per day, demonstrating its utility in analyzing rare cancers.

The paper introduces uMetaP, an ultra-sensitive metaproteomic method that enhances detection of the gut dark metaproteome and identifies drug targets in intestinal inflammatory diseases.

This study shows that LIN28A and CTNNB1 co-activation disrupts cortical neuronal migration and pia mater integrity, resembling Cobblestone lissencephaly.

The paper identifies TAOK2β as a regulator of translational elongation and shows its disruption leads to increased protein synthesis in an ASD mouse model.

The paper provides a comprehensive proteomic map of 13 human brain regions using high-throughput mass spectrometry, highlighting region-specific protein expression patterns and markers.

The paper shows that a mutation in CASK's CaMK domain disrupts its regulation of Liprin-α phase separation, leading to neurodevelopmental disorder with microcephaly and pontocerebellar hypoplasia.

This study characterizes brain-derived extracellular vesicles (sEVs) in mice under normal and post-stroke conditions, showing increased PrP and PrP-C1 content and altered cellular uptake.

This study identifies ID4 as a repressor of myoepithelial differentiation in mammary stem cells through its interaction with HEB, using integrated transcriptomic, proteomic, and ChIP-sequencing data.

This study identifies ID4's role in DNA damage response in BLBC and HGSOV by showing its interaction with MDC1 and DNA repair proteins, linking it to BRCA1-mutant tumors.