Origins of cell-to-cell variability, kinetic proof-reading and the robustness of MAPK signal transduction
Sarah Filippi, Chris P. Barnes, Paul Kirk, Takamasa Kudo, Siobhan McMahon, Takaho Tsuchiya, Takumi Wada, Shinya Kuroda, Michael P.H. Stumpf
The paper measures cell-to-cell variability in MAPK signaling and shows upstream noise drives ERK phosphorylation heterogeneity, with the system using kinetic proof-reading to robustly transmit signals.
bioRxiv · Jul 1, 2015 · PreprintSystems Biology