Author

Sarah Filippi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Siobhan McMahon· 2 shared Aaron Sim· 1 shared Ben D MacArthur· 1 shared Chris P. Barnes· 1 shared Heather Harrington· 1 shared Michael P.H. Stumpf· 1 shared Michael Stumpf· 1 shared Oleg Lenive· 1 shared

Activity by Year

2015-2016 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersSystems Biology

Siobhan McMahon

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3 papers

Recent·Most cited

Nanog fluctuations in ES cells highlight the problem of measurement in cell biology

Rosanna C G Smith, Patrick S Stumpf, Sonya J Ridden, Aaron Sim, Sarah Filippi, Heather Harrington, Ben D MacArthur

The paper shows that genetic reporters for Nanog can distort its dynamics in ES cells, leading to misleading results about pluripotency regulation.

bioRxiv · Jun 28, 2016Cell Biology

Information Processing by Simple Molecular Motifs and Susceptibility to Noise

Siobhan McMahon, Oleg Lenive, Sarah Filippi, Michael Stumpf

The paper quantifies how extrinsic and intrinsic noise affect information transmission in simple molecular motifs and explains how noise can create apparent information.

bioRxiv · Jul 31, 2015Systems Biology

Origins of cell-to-cell variability, kinetic proof-reading and the robustness of MAPK signal transduction

Sarah Filippi, Chris P. Barnes, Paul Kirk, Takamasa Kudo, Siobhan McMahon, Takaho Tsuchiya, Takumi Wada, Shinya Kuroda, Michael P.H. Stumpf

The paper measures cell-to-cell variability in MAPK signaling and shows upstream noise drives ERK phosphorylation heterogeneity, with the system using kinetic proof-reading to robustly transmit signals.

bioRxiv · Jul 1, 2015 · PreprintSystems Biology