Author

Paul Kirk

Primary ORCID profile (0000-0002-5931-7489 · 18 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Paul KirkiD18 papers · University of Cambridge

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:differential expression· 1 Assay:imaging· 1

Frequent Co-Authors

Adam L MacLean· 1 shared Chris P. Barnes· 1 shared Michael P.H. Stumpf· 1 shared Michael PH Stumpf· 1 shared Sarah Filippi· 1 shared Shinya KurodaiD· 1 shared Siobhan McMahon· 1 shared Takaho TsuchiyaiD· 1 shared

Activity by Year

2015-2015 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperSystems Biology

Adam L MacLean

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2 papers

Recent·Most cited

Cellular Population Dynamics Control the Robustness of the Stem Cell Niche

Adam L MacLean, Paul Kirk, Michael PH Stumpf

This study uses mathematical models to show that stem cell niche feedback increases stability and robustness in cell population dynamics, regardless of niche complexity.

bioRxiv · Jul 2, 2015Systems Biology

Origins of cell-to-cell variability, kinetic proof-reading and the robustness of MAPK signal transduction

Sarah Filippi, Chris P. Barnes, Paul Kirk, Takamasa Kudo, Siobhan McMahon, Takaho Tsuchiya, Takumi Wada, Shinya Kuroda, Michael P.H. Stumpf

The paper measures cell-to-cell variability in MAPK signaling and shows upstream noise drives ERK phosphorylation heterogeneity, with the system using kinetic proof-reading to robustly transmit signals.

bioRxiv · Jul 1, 2015 · PreprintSystems Biology