Takaho Tsuchiya

The paper examines metabolic adaptations during starvation in obese mice, finding impaired responsiveness and elevated enzyme expression in skeletal muscle and liver.

The paper examines how obesity disrupts the temporally ordered metabolic network in the liver during starvation, revealing structural robustness but temporal vulnerability.

CCPLS identifies cell-type-specific spatial dependencies on HVG expression variability using spatial transcriptome data.

This study uses multiomic analysis of skeletal muscle in obese and healthy mice to reveal differences in metabolic regulation by metabolites and genes after glucose administration.

The paper introduces MOCCS profiles to analyze DNA-binding specificity of TFs across cell types and shows that one-third of TFs exhibit cell-type-specific binding, with ΔMOCCS2scores predicting variant effects on TF binding.

The paper develops a system identification method using compressed sensing to analyze signaling-decoding systems with different time scales, revealing gene expression responses to signaling activation.

The paper measures cell-to-cell variability in MAPK signaling and shows upstream noise drives ERK phosphorylation heterogeneity, with the system using kinetic proof-reading to robustly transmit signals.