Differentiation Success of Reprogrammed Cells is Heterogenous In Vivo and Modulated by Somatic Cell Identity Memory
Tomáš Zikmund, Jonathan Fiorentino, Chris Penfold, Marco Stock, Polina S Shpudeiko, Gaurav Agarwal, Larissa Langfeld, Kseniya Petrova, Leonid Peshkin, Stephan Hamperl, Antonio Scialdone, Eva Hörmanseder
This study shows that reprogramming success varies by cell type and is influenced by the expression of genes from the original cell type, with some cells resisting reprogramming and causing developmental issues.
Stem Cell Reports · Mar 13, 2025Peer-reviewedDevelopmental Biology