Leonid Peshkin

The paper quantifies 3D cellular organization in two Xenopus species to show how tissue architecture converges despite differences in size and cell number.

The paper shows that protein accumulation upstream of Cdk1 activation regulates meiosis resumption timing and competence in oocytes through stepwise acquisition of regulatory mechanisms.

This study identifies kinases involved in cellular recovery after caspase activation using a kinome inhibitor screen, revealing roles for adhesion, cytoskeleton, and growth factor signaling.

The paper presents the first single-cell transcriptomic atlas of Daphnia magna, identifying over 30 cell types and providing insights into their functional roles and potential ecological adaptations.

The paper introduces a method to impute missing proteomics data using regularized regression and biological covariation, achieving high accuracy across multiple measurement modalities.

This paper introduces NoRI, a Raman imaging technique that enables quantitative, label-free analysis of kidney tissue, revealing sex-specific differences and dynamic changes in acute kidney injury.

The paper compares spinal cord cell types across vertebrates, finding conserved developmental programs and divergent adult compositions, with mammalian-specific neuropeptide expression in the dorsal spinal cord.

The paper analyzes proteome and phospho-proteome changes during Xenopus embryonic development, identifying key transitions in protein expression and phosphorylation patterns.

This study uses phosphoproteomics to analyze protein phosphorylation during Xenopus oocyte meiotic divisions, revealing key phosphorylation events and their roles in meiotic processes.

The paper shows that sperm-derived H2AK119ub1 is essential for embryonic development in Xenopus laevis by guiding epigenetic remodelling of paternal chromatin.

This study examines DNA methylation in Daphnia magna and finds no significant age-related changes in methylation patterns.

This study examines how pre- and post-fertilization X-ray exposure affects Xenopus laevis development, finding varying lethality and anomaly rates based on dose and timing.

This study shows that reprogramming success varies by cell type and is influenced by the expression of genes from the original cell type, with some cells resisting reprogramming and causing developmental issues.

This paper introduces a standardized protocol for efficient and comprehensive tissue sampling in adult Xenopus, enabling high-quality biochemical analyses across 18 tissues.

This paper develops an epigenetic clock for Xenopus tropicalis using DNA methylation data, finding age-associated CpG sites enriched in heterochromatin marks similar to mammals.

The paper analyzes RNAseq data from Daphnia magna to show that post-senescence reproductive events involve reversal of age-related transcriptional changes, suggesting potential mechanisms for reproductive rejuvenation.

This study examines baseline longevity of Daphnia magna clones under various conditions, finding strong genotype-by-environment interactions and differences in lifespan extension responses to caloric restriction.

The paper shows TNF synergizes with proteostatic stress to induce cell death and guard immunity against viral infection.

This paper identifies issues in lifespan studies due to lack of standardization and proposes solutions for improving data consistency and comparability.

This paper updates a single-cell transcriptomic atlas of Xenopus embryos, improving gene mapping, read counts, and cell type nomenclature while uncovering new transcription features in germ cells.

The paper identifies age-associated DNA methylation changes in Xenopus tropicalis using whole genome bisulfite sequencing and develops a cost-effective epigenetic clock assay.

The paper identifies kinases critical for endothelial cell proliferation across multiple pro-angiogenic growth factors using a quantitative assay and kinome regression.

The paper identifies gastrulation in Xenopus laevis as the stage with the lowest epigenetic age and highest developmental disruption, suggesting it as the onset of aging.

The paper investigates maternal age effects on offspring longevity and male production in Daphnia magna, finding a reverse Lansing effect and linking it to lipid provisioning and mitochondrial quality.

The paper maps the molecular timeline and regulatory networks driving neural crest emergence in Xenopus tropicalis using single-cell transcriptomics and machine learning.

Rapamycin treatment during early life extends lifespan and healthspan in mice and Daphnia magna by slowing development and delaying aging.

This paper introduces a new computational method for Quantitative Phase Microscopy to measure single-cell growth dynamics, revealing oscillatory growth patterns in mammalian cells.

The paper presents a dataset of kinase inhibitor profiles and introduces an improved method to identify key kinases involved in cellular phenotypes using quantitative assays and machine learning.

This study uses quantitative proteomics to analyze protein expression changes across life phases of Daphnia pulex, revealing functional shifts in response to environmental stress.

The paper introduces BACIQ, a method to calculate confidence intervals for multiplexed proteomics data by integrating peptide signal and measurement agreement, improving the detection of subcellular protein movement.