Stephan Hamperl

The rapid delivery of RNase H variants reveals distinct classes of RNA:DNA hybrids

The paper develops iCoRD to rapidly deliver RNase H1 in live cells and shows it affects specific RNA:DNA hybrids and replication fork stability.

Aquarius RNA helicase Protects Pluripotent Stem Cell Identity

This study identifies Aquarius RNA helicase as essential for maintaining genomic resilience and pluripotent stem cell identity by resolving transcription-replication conflicts.

SMAD4 loss drives cancer chromosomal instability through transcription-replication conflict-induced replication stress

This study shows SMAD4 loss causes cancer chromosomal instability by inducing replication stress through transcription-replication conflicts via BMP signaling.

Proximity of pre-mRNA 3' end processing and transcription termination predicts enhanced gene expression

The paper investigates how proximity of pre-mRNA 3' end processing and transcription termination affects gene expression in colorectal cancer, finding that closer proximity correlates with higher expression.

Replisome progression regulates R-loop mediated transcriptional repression

This study shows that replisome progression through R-loops reverses transcriptional repression and prevents fork stalling by reducing RNAPII density.

Differentiation Success of Reprogrammed Cells is Heterogenous In Vivo and Modulated by Somatic Cell Identity Memory

This study shows that reprogramming success varies by cell type and is influenced by the expression of genes from the original cell type, with some cells resisting reprogramming and causing developmental issues.

Rapid delivery of RNase H1 enables replication fork progression under stress independently of R-loop resolution

This study shows that rapid delivery of RNase H1 rescues replication fork progression under stress without affecting R-loops.

A phosphorylation code coordinating transcription condensate dynamics with DNA replication

This study identifies a phosphorylation code in MED1 that coordinates transcription condensate dynamics with DNA replication, showing its importance for histone biosynthesis and DNA damage prevention.

qDRIP: Quantitative differential RNA:DNA hybrid immunoprecipitation sequencing

qDRIP quantitatively compares RNA:DNA hybrids in different conditions to estimate their absolute counts and half-lives.