Author

Tomáš Zikmund

Helmholtz MunichORCID 0000-0003-2452-3749Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Eva HörmansederiD· 2 shared Marco StockiD· 2 shared Ana JanevaiD· 1 shared Antonio ScialdoneiD· 1 shared Axel ImhofiD· 1 shared Chris Penfold· 1 shared Christopher A. PenfoldiD· 1 shared Gaurav Agarwal· 1 shared

Activity by Year

2025-2025 · peak 2/yr

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10 top collaborators · 30 mutual co-author links

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2 shared papersDevelopmental Biology

Eva HörmansederORCID

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2 papers

Recent·Most cited

Developmental BiologyStem Cell ReportsPeer-reviewedMar 13, 2025

Differentiation Success of Reprogrammed Cells is Heterogenous In Vivo and Modulated by Somatic Cell Identity Memory

Tomáš Zikmund, Jonathan Fiorentino, Chris Penfold…·Eva Hörmanseder

This study shows that reprogramming success varies by cell type and is influenced by the expression of genes from the original cell type, with some cells resisting reprogramming and causing developmental issues.

3 citations

mouseexperimental assay

GenomicsbioRxivPreprintJan 22, 2025

Digital Reprogramming Decodes Epigenetic Barriers of Cell Fate Changes

Ana Janeva, Christopher A. Penfold, Sara Llorente-Armijo…·Eva Hörmanseder

This study identifies H3K27ac as an epigenetic barrier to reprogramming-induced cell fate changes using an AI-based approach and shows that reducing H3K27ac improves reprogramming efficiency.

DOI 10.1101/2025.01.22.634227

ChIP-seqbulk RNA-seq