Notch signaling maintains a progenitor-like subclass of hepatocellular carcinoma
Kerstin Seidel, Robert Piskol, Thi Thu Thao Nguyen, Amy Shelton, Charisa Cottonham, Cecile C. de la Cruz, Joseph Castillo, Jesse Garcia, Udi Segal, Mark A. Merchant, Yeqing Angela Yang, Jasmine Chen, Musa Ahmed, Alexis Scherl, Rajesh Vij, , Chris Siebel
This study identifies Notch-dependent progenitor-like HCCs that regress upon Notch inhibition, revealing a therapeutic target in a poor-prognosis subgroup.
bioRxiv · Dec 13, 2024 · PreprintCancer Biology