Author

Joseph Castillo

GenentechORCID 0000-0003-4080-2545Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alexis ScherliD· 1 shared Alfred C. ApliniD· 1 shared Amy Shelton· 1 shared Catarina de Andrade BarbozaiD· 1 shared Cecile C. de la Cruz· 1 shared Charisa CottonhamiD· 1 shared Chris Siebel· 1 shared Ciara MetcalfeiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alexis ScherlORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintFeb 22, 2026

Vascular Destabilization and Pericyte Detachment are Mediated by hIAPP Aggregation in Transgenic Mice.

J. P. Koepke, Luciana Mateus Gonçalves, Catarina de Andrade Barboza…·Rebecca L. Hull-Meichle

This study shows hIAPP aggregation disrupts islet microvascular stability by downregulating EC genes and causing pericyte detachment, impairing vasomotor responses.

DOI 10.64898/2026.02.21.707196

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintDec 13, 2024

Notch signaling maintains a progenitor-like subclass of hepatocellular carcinoma

Kerstin Seidel, Robert Piskol, Thi Thu Thao Nguyen…·Chris Siebel

This study identifies Notch-dependent progenitor-like HCCs that regress upon Notch inhibition, revealing a therapeutic target in a poor-prognosis subgroup.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky