Yeqing Angela Yang

The paper introduces CAT-ATAC, a method combining CRISPR, RNA, and ATAC-seq in single cells to identify gene regulatory relationships and validate them with loss-of-function experiments.

The paper develops a SAMHD1 knockout iPSC model that enhances lentiviral transduction efficiency in myeloid cells, enabling better functional genomics studies in innate immunity and inflammatory diseases.

This study identifies Notch-dependent progenitor-like HCCs that regress upon Notch inhibition, revealing a therapeutic target in a poor-prognosis subgroup.

This study identifies Dpt+ fibroblasts as essential for maintaining a Csf1-dependent macrophage niche in skin, with implications for wound healing and scleroderma.