Amyloid fibril polymorphism in the heart and the liver of an ATTR amyloidosis patient with polyneuropathy attributed to the ATTRv-V122Δ variant
Yasmin Ahmed, Binh An Nguyen, Candace Kelly, Shumaila Afrin, Virender Pratap Singh, Bret M. Evers, John Michael Shelton, Christian Lopez Escobar, Preeti Singh, Rose Pedretti, Lanie Wang, Parker T. Bassett, María del Carmen Fernández‐Ramírez, Maja Pękała, Andrew S. Lemoff, , Lorena Saelices
The paper uses cryo-electron microscopy to characterize amyloid fibrils from the heart and liver of an ATTRv amyloidosis patient with the V122Δ mutation, finding structural polymorphism linked to polyneuropathy.
bioRxiv · May 9, 2024 · PreprintMolecular Biology