Andrew S. Lemoff

This study shows that glutathione is essential for proteostasis in hematopoietic stem cells but not for ferroptosis prevention.

The paper shows mitochondrial state influences protein-level immune responses, with OXPHOS supporting early immune proteins and mitochondrial perturbation favoring inflammatory mediators in mice.

This study maps organ-specific endothelial surface proteomes in vivo to identify tissue-selective vascular targets for therapy.

This study identifies APOE4 as a risk factor for thrombosis by promoting vWF secretion through ApoER2 and PP2A activation in endothelial cells, leading to increased thrombosis in mice and human veins.

The paper develops a platform to trace 30 nitrogen isotope-labeled metabolites, revealing cell state-specific pyrimidine synthesis pathway preferences in primitive and differentiated cells.

This study uses cryo-EM to reveal structural polymorphism in ex-vivo ALECT2 amyloid fibrils, identifying three morphologies and acetylation sites.

This study shows that hyperosmolar stress increases the release of small extracellular vesicles containing metabolic proteins from corneal epithelial cells, suggesting a potential early indicator of dry eye disease.

The paper shows EPOP inhibits PRC2.1 by disrupting its dimerization, reducing chromatin association, and preventing over-repression of gene regulators during early differentiation.

This study shows that degrading tankyrase (TNKS) with PROTACs overcomes the limitations of catalytic inhibitors by preventing AXIN puncta formation and enhancing WNT/β-catenin pathway suppression in colorectal cancer.

The gut microbiota enhances translation of innate barrier defense proteins through HDAC5-mediated activation of mTORC1 signaling.

The paper determines the cryo-EM structures of three neuropathy-associated ATTR variants and reveals a shared amyloid core despite different mutations and clinical phenotypes.

This study uses cryo-EM to analyze structural variability of apolipoprotein A-I amyloid fibrils across organs and mutations, revealing conformational differences and potential clinical implications.

This study determines the structure of the Retriever-SNX17 complex using cryo-EM, revealing how SNX17 interacts with Retriever to facilitate endosomal sorting of cargo proteins.

This study determines the structure of ATTRv-V30M amyloid fibrils from cardiac and nerve tissues using cryo-EM, finding structural homogeneity across tissues when transthyretin originates from the liver.

The paper uses cryo-EM to show that cardiac ATTRwt amyloid fibrils from four patients are structurally identical, supporting their consistent clinical presentation.

The paper uses cryo-electron microscopy to characterize amyloid fibrils from the heart and liver of an ATTRv amyloidosis patient with the V122Δ mutation, finding structural polymorphism linked to polyneuropathy.