Author

Christian M. MacDonald

University of California, San Francisco

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Biophysics· 1

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Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

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Ian B. SeipleiD· 1 shared James S. FraseriD· 1 shared Pooja AsthanaiD· 1 shared Sonya Lee· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBiophysics

Ian B. SeipleORCID

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1 paper

Recent·Most cited

BiophysicsStructurePeer-reviewedSep 13, 2025

Initial leads to combat streptogramin resistance generated from X-ray fragment screening against VatD

Pooja Asthana, Sonya Lee, Christian M. MacDonald…·James S. Fraser

This study identifies fragment-based inhibitors of VatD, an enzyme responsible for streptogramin resistance, using X-ray crystallography to guide inhibitor development.

1 citation

bacteria (other)proteomics

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