simCRISPR: Modeling experimental complexity in pooled CRISPR screens
Zhaohan Zhu, Xiaoru Dong, Chanhee Kim, Christian Maugee, W. Brad Barbazuk, Chris D. Vulpe, Rhonda L. Bacher
The paper develops simCRISPR, a simulation framework for pooled CRISPR screens, evaluates normalization strategies for detecting gene-by-environment interactions, and shows improved results with safe-harbor normalization.
bioRxiv · May 15, 2026 · PreprintBioinformatics