Xiaoru Dong

The paper develops simCRISPR, a simulation framework for pooled CRISPR screens, evaluates normalization strategies for detecting gene-by-environment interactions, and shows improved results with safe-harbor normalization.

The paper introduces scLANE, an interpretable method for trajectory differential expression in single-cell RNA-seq, validated on simulations and applied to biological datasets.

The paper introduces Escort, a framework to evaluate dataset suitability for trajectory inference and quantify trajectory properties, reducing analysis uncertainty through data-driven assessments.