Chris D. Vulpe

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

This study shows that LRRK2 mutations disrupt iron homeostasis in neurons and astrocytes, leading to oxidative stress and ferroptosis.

The paper develops simCRISPR, a simulation framework for pooled CRISPR screens, evaluates normalization strategies for detecting gene-by-environment interactions, and shows improved results with safe-harbor normalization.

This paper identifies DH20931 as a first-in-class agonist of CerS2 that induces ER stress and apoptosis in TNBC cells, showing preclinical efficacy.

This paper develops a 3D CRISPR screening system using HepG2/C3A spheroids to improve the identification of genetic determinants of chemical toxicity compared to traditional 2D methods.

This study identifies 340 genes modulating PFOS-induced cytotoxicity in liver cells using CRISPR screens and validates two genes, SLC6A9 and CPSF2, with functional and molecular evidence.

The paper identifies C18orf32 as a novel regulator of lipid metabolism involved in PFOA-induced toxicity through CRISPR screening and transcriptomic analysis.

The paper identifies common loss-of-function genes and develops a method to integrate them into cell-based models to assess population variability in chemical susceptibility.

This study investigates the genetic basis of dietary iron overload and associated pathologies in mice using the Hybrid Mouse Diversity Panel, identifying genetic loci and pathways involved.