Frontotemporal Dementia Patient Neurons With Progranulin Deficiency Display Protein Dyshomeostasis
Lisa P. Elia, Bianca Herting, Amela Alijagic, Christina Buselli, Leela Wong, Grace Morrison, Miguel A. Prado, João A. Paulo, Steven P. Gygi, Daniel J. Finley, Steven M. Finkbeiner
This study uses patient-derived neurons to show that PGRN deficiency causes proteostasis breakdown and TDP-43 aggregation in FTD.
bioRxiv · Jan 18, 2023 · PreprintNeuroscience