Author
Instituto de Investigación Sanitaria del Principado de AsturiasORCID 0000-0002-4914-1619Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Ee Phie Tan, Lydia Ambaye, Anne-Laure Mahul-Mellier…·Jeffery W. Kelly
AA-20 promotes lipophagy by activating lysosomal acid lipase and CDK5, reducing lipid droplet accumulation and improving neurodegeneration-associated phenotypes in cellular and organoid models.
Suzanne Elsasser, Evan T. Powers, Thomas Stoeger…·Daniel J. Finley
The paper provides a comprehensive survey of the ubiquitin-proteasome system (UPS) and estimates its size and scope within the human proteostasis network.
Bryan D. Ryder, N. Yan, Danna Trejos-Vidal…·Jason E. Gestwicki
This study identifies a conserved leucine in the C-terminus of proteasome activators as essential for gate opening of the human 20S proteasome, with structural and functional evidence supporting its role.
Lisa P. Elia, Bianca Herting, Amela Alijagic…·Steven M. Finkbeiner
This study uses patient-derived neurons to show that PGRN deficiency causes proteostasis breakdown and TDP-43 aggregation in FTD.