Daniel J. Finley

The paper provides a comprehensive survey of the ubiquitin-proteasome system (UPS) and estimates its size and scope within the human proteostasis network.

This study reveals how UBE3C reprograms the proteasome to degrade ultra-stable protein folds by bypassing USP14 and enhancing substrate unfolding.

The paper quantifies proteasome re-organization during proteotoxic stress using single-molecule microscopy and shows cytoskeleton-dependent movement restrictions.

The paper curates a list of 838 high-confidence components of the autophagy-lysosome pathway as part of a comprehensive effort to define the human proteostasis network.

This study uses patient-derived neurons to show that PGRN deficiency causes proteostasis breakdown and TDP-43 aggregation in FTD.

The paper defines and annotates 959 genes comprising the human proteostasis network, focusing on translation, protein folding, and organelle-specific systems.