N1-methylation of adenosine (m1A) in ND5 mRNA leads to complex I dysfunction in Alzheimer's disease
Marko Jörg, Johanna E. Plehn, Marco Kristen, Marc Lander, Lukas Walz, Christine Lietz, Julie Wijns, Florian Pichot, Liliana Rojas-Charry, Kellie Martin, Nicolas Ruffini, Nastasja Kreim, Susanne Gerber, Yuri Motorin, Kristina Endres, , Kristina Friedland
The paper shows that m1A methylation of ND5 mRNA, catalyzed by TRMT10C, leads to translation repression and mitochondrial dysfunction in Alzheimer's disease.
Molecular Psychiatry · Jan 29, 2024Peer-reviewedNeuroscience