Author

Lukas Walz

Johannes Gutenberg University Mainz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Kristina FriedlandiD· 3 shared Mark HelmiD· 3 shared Marko JörgiD· 3 shared Kristina EndresiD· 2 shared Marc LanderiD· 2 shared Susanne GerberiD· 2 shared Anna WierczeikoiD· 1 shared Axel MethneriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersNeuroscience

Kristina FriedlandORCID

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3 papers

Recent·Most cited

Sex-specific remodeling of the tRNA epitranscriptome in Alzheimers disease

Marko Jörg, Lukas Walz, Marc Lander, Larissa Bessler, Sebastian Nathal, Kristine Freude, Kristina Endres, Mark Helm, Kristina Friedland

The paper identifies sex-specific changes in the tRNA epitranscriptome in Alzheimer's disease models and human tissue, and develops a tRNA modification score linked to disease severity.

bioRxiv · Apr 2, 2026 · PreprintNeuroscience

ModiDeC: a multi-RNA modification classifier for direct nanopore sequencing

Nicolò Alagna, Stefan Mündnich, Johannes Miedema, Stefan Pastore, Lioba Lehmann, Anna Wierczeiko, Johannes Friedrich, Lukas Walz, Marko Jörg, Tamer Butto, Kristina Friedland, Mark Helm, Susanne Gerber

ModiDeC is a deep-learning classifier that identifies multiple RNA modifications from direct nanopore sequencing, validated on synthetic data and biological samples.

Nucleic Acids Research · Jul 19, 2025Peer-reviewedBioinformatics

N1-methylation of adenosine (m1A) in ND5 mRNA leads to complex I dysfunction in Alzheimer's disease

Marko Jörg, Johanna E. Plehn, Marco Kristen, Marc Lander, Lukas Walz, Christine Lietz, Julie Wijns, Florian Pichot, Liliana Rojas-Charry, Kellie Martin, Nicolas Ruffini, Nastasja Kreim, Susanne Gerber, Yuri Motorin, Kristina Endres, , Kristina Friedland

The paper shows that m1A methylation of ND5 mRNA, catalyzed by TRMT10C, leads to translation repression and mitochondrial dysfunction in Alzheimer's disease.

Molecular Psychiatry · Jan 29, 2024Peer-reviewedNeuroscience