Author

Nastasja Kreim

Institute of Molecular Biology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:Drosophila· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

Jean‐Yves RoignantiD· 3 shared Giriram MohanaiD· 2 shared Axel MethneriD· 1 shared Christine Lietz· 1 shared Daniel Brüne· 1 shared Fédérico MariniiD· 1 shared Florian PichotiD· 1 shared Harald BinderiD· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersDevelopmental Biology

Jean‐Yves RoignantORCID

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4 papers

Recent·Most cited

Tissue specific function of the Drosophila 7SK snRNP in controlling motoneuron synaptic growth

Giriram Mohana, Nastasja Kreim, Jean‐Yves Roignant

This study shows that loss of Larp7 or 7SK RNA in Drosophila impairs locomotion and axonal growth, with the 7SK complex regulating transcription of long genes with high GC content promoters.

bioRxiv · Apr 29, 2025 · PreprintDevelopmental Biology

N1-methylation of adenosine (m1A) in ND5 mRNA leads to complex I dysfunction in Alzheimer's disease

Marko Jörg, Johanna E. Plehn, Marco Kristen, Marc Lander, Lukas Walz, Christine Lietz, Julie Wijns, Florian Pichot, Liliana Rojas-Charry, Kellie Martin, Nicolas Ruffini, Nastasja Kreim, Susanne Gerber, Yuri Motorin, Kristina Endres, , Kristina Friedland

The paper shows that m1A methylation of ND5 mRNA, catalyzed by TRMT10C, leads to translation repression and mitochondrial dysfunction in Alzheimer's disease.

Molecular Psychiatry · Jan 29, 2024Peer-reviewedNeuroscience

The exon junction complex regulates the release and phosphorylation of paused RNA polymerase II

Junaid Akhtar, Nastasja Kreim, Fédérico Marini, Giriram Mohana, Daniel Brüne, Harald Binder, Jean‐Yves Roignant

The paper shows that the pre-EJC regulates RNA polymerase II pausing and prevents premature elongation, with consequences for exon skipping and differentiation.

bioRxiv · Feb 25, 2018 · PreprintMolecular Biology

Comprehensive Characterization Of The Complex Lola Locus Reveals A Novel Role In The Octopaminergic Pathway Via Tyramine Beta-Hydroxylase Activation

Nadja Dinges, Violeta Morı́n, Nastasja Kreim, Tony D. Southall, Jean‐Yves Roignant

The paper characterizes the complex Lola locus in Drosophila by generating isoform-specific mutations, revealing distinct roles in axon guidance and neurodegeneration via the octopaminergic pathway.

Cell Reports · Dec 1, 2017Peer-reviewedNeuroscience