Marko Jörg

The paper identifies sex-specific changes in the tRNA epitranscriptome in Alzheimer's disease models and human tissue, and develops a tRNA modification score linked to disease severity.

This paper demonstrates real-time transcriptomic analysis using nanopore sequencing for quality control and differential expression in various experimental conditions.

This study identifies potent DNMT2 inhibitors through DNA-encoded library screening, revealing a cryptic allosteric binding site and optimizing an inhibitor with low nanomolar affinity.

ModiDeC is a deep-learning classifier that identifies multiple RNA modifications from direct nanopore sequencing, validated on synthetic data and biological samples.

This paper identifies SV2A as a mitochondrial outer membrane protein that regulates mitochondrial morphology and autophagy through interactions with DRP1 and ATG9A.

The paper shows that m1A methylation of ND5 mRNA, catalyzed by TRMT10C, leads to translation repression and mitochondrial dysfunction in Alzheimer's disease.