Dynamic regulation of NeuroD1 expression level by a novel viral construct during astrocyte-to-neuron reprogramming
Natalie Mseis-Jackson, Mei Hua Jiang, Mehek Sharma, Arya Ranchod, Christine Williams, Xuanyu Chen, Hedong Li
This study introduces a viral construct that dynamically regulates NeuroD1 expression during astrocyte-to-neuron reprogramming, reducing its level in reprogrammed neurons to enhance GABAergic differentiation.
Molecular Therapy — Nucleic Acids · Sep 5, 2025Peer-reviewedNeuroscience