Small heat shock protein HSPB5 uses disorder to bind zinc with high affinity.
Maria K. Janowska, Vanesa Racigh, Christoper N. Woods, Marı́a Silvina Fornasari, Rachel E. Klevit
This study shows HSPB5 binds zinc with high affinity using its disordered N-terminal region, acting as a zinc reservoir under oxidative stress.
Journal of Biological Chemistry · Dec 10, 2025Peer-reviewedBiophysics