Maria K. Janowska

Function within Disorder: Small heat shock proteins use different functional regions to chaperone tau aggregation

This study shows HSPB1 and HSPB5 use distinct N-terminal regions to delay tau aggregation, with HSPB1 under normal conditions and HSPB5 under stress.

Ultra-slow conformational dynamics and catch bond formation of a Bacterial Adhesin revealed by a single-domain variant of FimH.

This study investigates FimH conformational dynamics and catch bond formation using a single-domain variant, revealing ultra-slow dynamics and a dynamic allosteric mechanism.

Small heat shock protein HSPB5 uses disorder to bind zinc with high affinity.

This study shows HSPB5 binds zinc with high affinity using its disordered N-terminal region, acting as a zinc reservoir under oxidative stress.

Disorder with consequence: Phosphorylation sites in HSPB5 yield distinct structural outcomes

This study examines how phosphorylation at different sites in HSPB5 affects its oligomeric structure and function, revealing distinct cellular outcomes based on the extent of phosphorylation.