A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice
Destynie Medeiros, Karen Ayala-Baylon, Hailey X. Egido‐Betancourt, Eric C. Miller, Christopher A. Chapleau, Holly Robinson, Mary L. Phillips, Tao Yang, Frank M. Longo, Wei Li, Lucas D. Pozzo‐Miller
This study shows that the small-molecule TrkB agonist LM22A-4 improves dendritic spine morphology and reduces aggressive behaviors in female Rett syndrome mice.
Disease Models & Mechanisms · May 24, 2024Peer-reviewedNeuroscience