Lucas D. Pozzo‐Miller

This study shows that MeCP2 in Purkinje cells is critical for precise timing and coordination in cerebellar learning but not for general motor behaviors.

This paper shows that astrocytes process neuromodulatory inputs into distinct temporal signals that modulate synaptic pathways and learning, with dynamics similar to neural network critic mechanisms.

This study shows that male Mecp2 knockout mice exhibit altered social behavior and reduced mPFC pyramidal neuron synchrony during social competition, which can be partially restored by inhibiting ventral hippocampus projections.

The paper investigates altered neuronal activity in the mPFC of Mecp2 knockout mice during social interactions, linking it to social memory impairments.

The paper shows that expressing wildtype MeCP2 or using G418 treatment in R255X MECP2 knock-in neurons restores cellular phenotypes to wildtype levels.

This study shows that Stem Cell Factor enhances inhibition of Purkinje Cells via presynaptic Kit, leading to long-term suppression of firing and specific potentiation of basket cells.

This study shows that the small-molecule TrkB agonist LM22A-4 improves dendritic spine morphology and reduces aggressive behaviors in female Rett syndrome mice.

This study investigates long-term structural changes in hippocampal dendritic spines during memory reconsolidation and finds that spine morphology, not density, is affected, with NF-κB inhibition modulating these changes.

This study identifies phosphatidylserine (PS) as a critical lipid for ASIC1a synaptic targeting and function through electrostatic interactions.

The paper identifies a mechanism by which glutamatergic and dopaminergic signaling integrate to regulate PKA via RII{beta} phosphorylation, affecting synaptic plasticity and stress responses.

The paper shows that GluN2B-containing NMDA receptors differ between ipsilateral and contralateral cortico-striatal synapses, leading to opposite long-term plasticity and distinct dopaminergic modulation.

This study shows that hyperactivity in the vHIP-mPFC projection impairs social memory in Mecp2 KO mice, and inhibiting this pathway rescues deficits.