Molecular basis for multidrug efflux by an anaerobic RND transporter
Ryan Lawrence, Mohd Athar, Muhammad Ramiz Uddin, Christopher Adams, Joana S. Sousa, Oliver Durrant, Sophie Lellman, Leslie N. Sutton, Charles William Keevil, Nisha Patel, Christine E. Prosser, David McMillan, Helen I. Zgurskaya, Attilio Vittorio Vargiu, Zainab Ahdash, Eamonn Reading
The paper investigates the molecular mechanism of MdtF, an RND transporter in E. coli, revealing structural and functional adaptations for multidrug efflux under anaerobic and acidic conditions.
Nature Communications · Dec 3, 2025Peer-reviewedBiochemistry