Author

Joana S. Sousa

The Francis Crick InstituteORCID 0000-0001-5325-060XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alessandro CostaiD· 1 shared Ambrosius P. SnijdersiD· 1 shared Andrea NansiD· 1 shared Attilio Vittorio VargiuiD· 1 shared Charles William KeeviliD· 1 shared Christine E. Prosser· 1 shared Christopher Adams· 1 shared David McMillaniD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Alessandro CostaORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedDec 3, 2025

Molecular basis for multidrug efflux by an anaerobic RND transporter

Ryan Lawrence, Mohd Athar, Muhammad Ramiz Uddin…·Eamonn Reading

The paper investigates the molecular mechanism of MdtF, an RND transporter in E. coli, revealing structural and functional adaptations for multidrug efflux under anaerobic and acidic conditions.

4 citations

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Molecular BiologyMolecular CellPeer-reviewedAug 4, 2020

A Structure-Based Mechanism for DNA Entry into the Cohesin Ring

Torahiko L. Higashi, Patrik Eickhoff, Joana S. Sousa…·Frank Uhlmann

This study uses cryo-EM and biochemical experiments to reveal the mechanism of DNA entry into the cohesin ring, showing how ATP binding and hydrolysis regulate the process.

154 citationstop 1%

experimental assay

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