The essential co-chaperone Sgt1 regulates client dwell time in the Hsp90 chaperone cycle
Sonja Engler, Florent Delhommel, Christopher Dodt, Abraham López, Ofrah Faust, Annika R. Elimelech, Valeria Napolitano, Grzegorz M. Popowicz, Rina Rosenzweig, Michael Sattler, Johannes Büchner
This study identifies Sgt1 as an essential co-chaperone that stabilizes Hsp90-client complexes and prevents dissociation by Aha1, enhancing client maturation efficiency.
Molecular Cell · Dec 22, 2025Peer-reviewedBiochemistry