Valeria Napolitano

The essential co-chaperone Sgt1 regulates client dwell time in the Hsp90 chaperone cycle

This study identifies Sgt1 as an essential co-chaperone that stabilizes Hsp90-client complexes and prevents dissociation by Aha1, enhancing client maturation efficiency.

Target Preference Maps: A machine learning model generalizing transferable drug-receptor interactions and guiding drug discovery

The paper introduces a machine learning model that learns spatial preference maps for drug-receptor interactions to guide drug discovery.

Quantum Chemistry in a Pocket: A Multifaceted Tool to Link Structure and Activity

The paper introduces an algorithm for optimizing protein-ligand complex structures, improving data curation and analysis for drug discovery.