Medial preoptic area FoxO1 controls metabolic adaptation in a sexually dimorphic manner
Pei Luo, Xiaohua Yang, Qi Xu, Lau Lee How, Valeria C. Torres Irizarry, LESLIE CARRILLO-SÁENZ, Marcos David Munoz, Wei Dong, Lucas Ibrahimi, Sarah Schaul, Nirali Patel, NIMISHA ANTONY, Devin Dixit, Maya Kota, Christopher Freeman, , Pingwen Xu
This study shows FoxO1 in the medial preoptic area (MPOA) influences metabolic adaptation to diet and temperature, with effects specific to female mice.
bioRxiv · Jun 25, 2025 · PreprintPhysiology