Pingwen Xu

This study shows that a single-point mutation in Kir2.1 channels protects mice from diet-induced obesity by altering fat distribution and increasing energy expenditure.

This study shows FoxO1 in the medial preoptic area (MPOA) influences metabolic adaptation to diet and temperature, with effects specific to female mice.

This study shows that estrogen signaling through ER and ERβ in 5-HTDRN neurons influences binge drinking behavior in mice, with ER agonists reducing alcohol-induced neuronal activity and binge drinking.

This study identifies estrogen receptor α's role in enhancing ethanol excitation of VTA dopamine neurons and binge drinking in female mice, highlighting sex-specific mechanisms in alcohol use disorder.

This study identifies α-ketoglutaric acid (AKG) as a metabolite that promotes muscle hypertrophy and fat loss via OXGR1-dependent adrenal activation in response to resistance exercise.