ADSoluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression
Suman De, Daniel R. Whiten, Francesco Simone Ruggeri, Craig D. Hughes, Margarida Rodrigues, Dimitrios I. Sideris, Christopher G. Taylor, Francesco A. Aprile, Serge Muyldermans, Tuomas P. J. Knowles, Michele Vendruscolo, Clare Elizabeth Bryant, Kaj Blennow, Ingmar Gr. Skoog, Silke Kern, , David Klenerman
The paper examines soluble Aβ aggregates in CSF from AD, MCI, and healthy controls, finding stage-specific differences in aggregate size and toxicity mechanisms.
Acta Neuropathologica Communications · Jul 26, 2019Peer-reviewedNeuroscience